Evaluate the evidence that regulatory T cells maybe be successfully Research Paper

Evaluate the usher that regulatory T cells maybe be successfully used to prevent implant versus entertain indisposition - Research Paper ExampleA main immunological technique that is used to measure regulatory T cell frequency is flow cytometry other methods used are immunohistochemistry staining involving studying scramble biopsies and ELISAs. All evidence proved strong in correlation with the hypothesis and suggests that CD4 CD25 FOXP3 Tregs could provide a prospective for the treatment of GvHD.Transplantation is the process of obtaining tissues or organs or cells and placing them in the same or polar individual. The organs, tissues and cells that are transferred from one individual to another are called transplants. The person who donates the graft is called sponsor and the one who recieves the graft is called recipient. Heart, kidney, cornea, liver, pancreas, lungs and bone marrow are transplanted from one person to another. There are two types of transplantation autopla sty (transplant from one region to another of the same indivudual and Syngraft or Isograft (Transfer of graft between individuals of same species). ( Khan, 2009).Graft versus armament disease is the series of events that occurs after(prenominal) the transplantation of the donor T cells with the stem cell graft. This is a donor T-cell mediated syndrome where the T cells in the graft shows their immune response. This response creates tissue damage. ( Beres and Drobyski, 2013). This is the major difficulty after the stem cell transplantation. The T-cells can recognise the minor and major histocompatibility antigens that are expressed at the host antigen presenting cells. The T-cells gets activated and expands and finally infiltrates and destroys the Graft versus host disease target tissues. The major tissues targeted are liver, gut and skin. This graft versus host hematopoiesis effect is the target for the allogenic stem cell transplantation. (Edinger, 2009). The rejection of the hos t may occur in first 100 days, where the donor immune cells recognize and attack the host tissues. As